Breast cancer patients with leptomeningeal carcinomatosis: Treatment results and validation of prognostic indexes
نویسندگان
چکیده
منابع مشابه
Intrathecal Trastuzumab Treatment in Patients with Breast Cancer and Leptomeningeal Carcinomatosis.
Leptomeningeal carcinomatosis is a fatal manifestation of metastatic breast cancer. Investigation of intrathecal (IT) trastuzumab for leptomeningeal carcinomatosis is currently underway; however, there has been no consensus. We report on two cases of human epidermal growth factor receptor 2 positive (HER2+) breast cancer following IT trastuzumab for leptomeningeal carcinomatosis. The first pati...
متن کاملOccult Breast Cancer Presenting as Leptomeningeal Carcinomatosis
Leptomeningeal carcinomatosis (LC) is a rare and devastating metastatic manifestation of both liquid and solid tumors consisting of dissemination of malignant cells with invasion into the meninges. Few options exist in most clinical situations, especially when LC is the presenting sign of occult malignancy. The prognosis is often poor with limited survival. Aims of palliation must be considered...
متن کاملNeuroborreliosis Mimicking Leptomeningeal Carcinomatosis in a Patient With Breast Cancer
Leptomeningeal carcinomatosis is a serious complication of advanced cancer. Various clinical manifestations may present, such as headache, nausea, seizures, cranial neuropathies. In this article, we report the case of a 65-year-old woman with metastatic breast cancer who was admitted to hospital suffering from facial palsy, which was suspected to be caused by leptomeningeal tumor infiltration. ...
متن کاملIncidence and Risk Factors for Leptomeningeal Carcinomatosis in Breast Cancer Patients with Parenchymal Brain Metastases
OBJECTIVE The objective of study is to evaluate the incidence of leptomeningeal carcinomatosis (LMC) in breast cancer patients with parenchymal brain metastases (PBM) and clinical risk factors for the development of LMC. METHODS We retrospectively analyzed 27 patients who had undergone surgical resection (SR) and 156 patients with whole brain radiation therapy (WBRT) as an initial treatment f...
متن کاملHashimoto's encephalopathy as the cause of deteriorating consciousness during treatment of leptomeningeal carcinomatosis from breast cancer.
Case Report A 53-year-old woman was diagnosed with breast cancer, and the pathologic results showed hormone-receptor–positive, HER2/neu– negative invasive lobular carcinoma in December 2007. The patient underwentamodifiedradicalmastectomyfollowedbyadjuvantchemotherapy, radiotherapy, and tamoxifen treatment immediately after the diagnosis. Unfortunately, a recurrence with a solitary brain metast...
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ژورنال
عنوان ژورنال: European Journal of Cancer
سال: 2020
ISSN: 0959-8049
DOI: 10.1016/s0959-8049(20)30701-2